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An earthy, hoppy terpene shared between cannabis and hops, studied for potential appetite-suppressing and anti-inflammatory properties.
Humulene is an earthy, woody terpene with subtle hoppy notes, named after Humulus lupulus, the common hop plant used in brewing. It shares a molecular formula with caryophyllene (they are isomers) but produces distinct aromas and effects. Humulene is also found in sage, ginseng, and ginger.
Humulene is one of the few terpenes studied for appetite-suppressing properties, which contrasts with the appetite-stimulating effects typically associated with cannabis. Research in Frontiers in Pharmacology has explored humulene's anti-inflammatory effects, finding it comparable to the steroid dexamethasone in some animal models. Additional studies suggest potential antibacterial and anti-tumor properties, though human clinical trials are still needed.
Humulene is found in notable strains including Death Star, Headband, White Widow, Girl Scout Cookies, and Sherbert. It rarely dominates a terpene profile but frequently appears as a secondary or tertiary terpene that adds complexity to the aroma and may contribute to the entourage effect. For consumers interested in cannabis without strong appetite stimulation, looking for strains with meaningful humulene content could be a useful strategy.
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