Linalool

Linalool is an acyclic monoterpenoid alcohol (C₁₀H₁₈O) found in over 200 species of plants. It exists as two enantiomers: (S)-linalool, prevalent in coriander and sweet orange, and (R)-linalool, the form dominant in lavender and basil. Its distinctive floral aroma—reminiscent of French lavender and lily of the valley—has made it one of the most widely used fragrance compounds in the world.

Linalool has been extensively studied for its anxiolytic (anti-anxiety) and sedative properties. In aromatherapy, lavender essential oil—rich in linalool—is the most commonly used oil for relaxation and sleep support. Research suggests it modulates the neurotransmitter glutamate and GABA, producing calming effects. It also demonstrates anti-inflammatory, antimicrobial, and antifungal properties. The FDA recognizes linalool as GRAS for use in food and cosmetics.

In cannabis, linalool-dominant strains are prized for their deeply calming effects. They are often recommended for anxiety, stress, insomnia, and pain. Linalool may also contribute to the “entourage effect” by enhancing the absorption and efficacy of cannabinoids like CBD.