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A cannabinoid that originates from plants rather than being produced by the human body, as found in cannabis.
A phytocannabinoid is any cannabinoid compound that originates from a plant, as opposed to endocannabinoids produced by the body or synthetic cannabinoids made in a laboratory. The prefix phyto comes from the Greek word for plant. Cannabis is by far the richest source of phytocannabinoids, producing over 100 unique compounds in this class.
The major phytocannabinoids include THC, CBD, CBG, CBN, CBC, THCV, and their acidic precursors (THCA, CBDA, CBGA). Each has a distinct molecular structure and interacts with the endocannabinoid system differently. THC is the primary psychoactive phytocannabinoid, while CBD, CBG, and CBC are non-intoxicating. Cannabis is not the only plant that produces cannabinoid-like compounds: Echinacea, black pepper (beta-caryophyllene), and liverwort (perrottetinene) also contain phytocannabinoids, though none approach the diversity or potency of cannabis.
The term phytocannabinoid is useful for distinguishing plant-derived cannabinoids from synthetic alternatives, which can carry different safety profiles and legal classifications. Synthetic cannabinoids like those found in products sold as Spice or K2 are designed to bind to the same receptors but can be far more potent and dangerous. When product labels and research papers use the term phytocannabinoid, they are confirming that the compound comes from a natural plant source.