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An endocannabinoid produced naturally in the brain, sometimes called the bliss molecule, that binds to CB1 receptors.
Anandamide is one of the two primary endocannabinoids produced naturally by the human body. Its name comes from the Sanskrit word ananda, meaning bliss, reflecting its role in producing feelings of pleasure and well-being. Anandamide was first identified in 1992 by Czech chemist Lumir Hanus and American pharmacologist William Devane in Raphael Mechoulam's laboratory.
Anandamide binds to CB1 receptors in the brain, the same receptors that THC targets, but with weaker affinity and much shorter duration. It is produced on demand when the body needs it, rather than being stored. After signaling, anandamide is rapidly broken down by the enzyme fatty acid amide hydrolase (FAAH). This quick degradation is why anandamide's effects are subtle and transient compared to THC. Activities like exercise, chocolate consumption, and even social bonding have been shown to temporarily elevate anandamide levels, which may explain the runner's high phenomenon.
THC produces its psychoactive effects precisely because it mimics anandamide at CB1 receptors but resists enzymatic breakdown, creating a stronger and longer-lasting signal. CBD may indirectly boost anandamide levels by inhibiting the FAAH enzyme that degrades it, which is one proposed mechanism for CBD's anti-anxiety effects. Research into anandamide has also revealed genetic variations in FAAH activity, which may explain why some people are naturally more relaxed or more sensitive to cannabis than others.
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